Christopher S. Lange

Christopher Lange
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Christopher S. Lange's Biography

Type Of Business:
College of medicine and school of graduate studies
Marketing Area:
Biophysical and biological research relating to human medical problems, particularly cancer and its treatment; Stem cells; Cancer stem cells; Aging; Embryology and regeneration; Molecular basis of cellular radio sensitivity; DNA double-strand breaks (DSBs) and their repair in mammalian cells; Mammalian chromosome structure
Major Product/SVS:
Higher education and health services
Favorite Business Publication:
Radiation Research; International Journal of Radiation Biology; International Journal of Radiation Oncology, Biology & Physics; Science
Political economy; Skiing
Education Degrees:
D.Phil. in Radiation Biophysics, Faculty of Medicine, University of Oxford (1968); Bachelor of Science in Physics, Minors in Biology, Chemistry, and Philosophy, MIT (1961)
Affiliations Awards:
Committee Person, 60th ED, 16th AD, Village of Flower Hill (1986-Present); Executive Committee, Town of North Hempstead Democratic Party, Nassau County, NY (1988-2009); Executive Committee, Nassau County Democratic Party, NY (1988-2009); Zone Chairman, Manhasset Zone, 16th AD (1987-2009); The New York Academy of Sciences; Radiation Research Society; American Association for the Advancement of Science; Sigma Xi, The Scientific Research Society; European Society for Radiation Biology; American Association for Cancer Research
Radiation Oncology
State/Country of Origin:
Date of Distinction:
Work History:
MRC Research Assistant, Churchill Hospital, Headington, Oxfordshire, UK (1961-62); Research Officer, Paterson Laboratories, Christie Hospital & Holt Radium Inst., Manchester, UK (1962-68); Sr. Res Officer, ibid. (1968-69); Assistant Professor of Radiology and Radiation Biology & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY (1969-80); Professor of Radiation Oncology, SUNY Downstate Medical Center (1980-Present), Professor of Biophysics & Physiology, ibid., (1980-90), Professor of Molecular & Cell Biology, ibid., (1990-Present), Associate Director Residency Program, ibid., (2008-Present), Associate Chair Radiation Oncology, ibid., (2010-Present).
Career Achievements:
International Patent application number PCT/US2008/004247, titled "Methods of Assaying Sensitivity of Cancer Stem Cells to Therapeutic Modalities" was filed in the United States Patent and Trademark Office on March 31, 2008 on behalf of The Research Foundation of SUNY and Drs. C.S. Lange, B. Djordjevic and M. Rotman (2008); International Patent Application No. WO 2008/121417 A1: "Methods of Assaying Sensitivity of Cancer Stem Cells to Therapeutic Modalities" was filed with the World Intellectual Property Organization on October 9, 2008 on behalf of The Research Foundation of SUNY and Drs. C.S. Lange, B. Djordjevic and M. Rotman (2008); Invention No. RF1907-100 “Production and secretion of protegrins, a broad spectrum bacteriocidal and mycocidal class of agents, from conditionally immortalized normal human diploid fibroblasts in vitro." Dr. C.S. Lange; U.S. Patent # 6,020,146. Carcinogenicity Testing System. Bozidar Djordjevic. The Research Foundation of SUNY. Feb. 1, 2000; Invention No. R-312, "A Clinical Assay for Radiation Therapy Treatment Planning." C.S. Lange and J.Y. Ostashevsky; Invention No. R-283, "The Use of Viscoelastometry to Determine Secondary and Tertiary Molecular Structures." C.S. Lange and J.Y. Ostashevsky; Invention No. S-280, "Control of Diffusion-Controlled Reactions by Solvent Viscosity and Temperature Control," C.S. Lange and J.Y. Ostashevsky; Publication of numerous seminal papers
Throughout the duration of your career, what was the one highlight that stood out the most?:
The highlights of his career are numerous, including the discovery that survival of organisms and their tissues can be understood quantitatively in terms of their stem cells; of the cellular basis of organismal aging; of the basis of organismal polarity control; that DNA double strand breaks are reparable and that irradiated cell survival can be understood in terms of their repair kinetics; of the structure of interphase mammalian chromosomes (clustered loop model); and development of an assay for individual patient cancer stem cell sensitivity to potential treatments, potentially allowing the selection of the best for each patient.
Number Of Years In Profession:
Number Of Years In Current Position:
What Does He/She Attribute Success To:
He attributes his success to his curiosity and training. His entire career demonstrates his ability to challenge paradigms, create new ones, take intellectual risks, and integrate diverse sources of information.
Why did you become involved in your profession or industry?:
He became involved in his profession because he asked questions; he made his own biophysics program for his bachelor's degree in physics). He then became interested in stem cell biology, which was new at the time, and obtained his doctorate with work demonstrating that the life of the organism can be understood in terms of its stem cells. His career has progressed ever since.
Extended Bio Profile:
Dr. Lange changed the fields of embryology and regeneration when he explained the mechanism of anterior-posterior (AP) polarity control. He showed that the AP morphogenetic field, as described in the textbooks, incorrectly predicted the results of transplantation and regeneration experiments. This is yet another model of his that changed paradigms and textbooks and remains unchallenged.

Additionally, Dr. Lange was the first to show that DNA double-strand breaks (DSBs) in mammalian cells are reparable. He also (with J.Y. Ostashevsky) created a quantitative basis for the molecular understanding of cell survival (the DSB model). He made several further significant changes in this field. He also (with J.Y. Ostashevsky) invented the clustered loop model of higher eukaryotic (mammalian) interphase chromosome structure.

Prof. Lange received his S.B. in Physics from MIT and his doctorate (D.Phil., Fac. Med.) from Oxford University. While an NHS Research Officer at the Christie Hospital & Holt Radium Institute, he explained organismal survival and aging in terms of stem cells. At the University of Rochester School of Medicine & Dentistry, he showed that DNA double-strand breaks (DSBs) are reparable in mammalian cells and he explained polarity control: how a planarian mid-piece knows on which end to regenerate the head. As Professor of Radiation Oncology and Molecular & Cell Biology at SUNY Downstate Medical Center, he showed that: (1) DNA DSB rejoining kinetics predict the survival of irradiated cells; (2) polymer theory and his clustered loop model explain the shape and dynamic behavior of mammalian chromosomes; and (3) he developed (and patented) the Hybrid Spheroid Assay which measures the sensitivity of individual patient cancer stem cells (CSCs) to each component of a proposed therapy, to be able to individualize patient treatments and speed anti-cancer agent development. His many honors include: The Knight’s Cross, Order of Merit, Republic of Poland; Marquis Who’s Who in the World; and Scientific Adviser to the New York State Assembly.
Position Responsibilities and Duties:
Running the research division of the radiation oncology department, as well as the radiation biology division, for teaching residents; Reviewing articles for over 20 journals, including Radiation Research, International Journal of Radiation Biology, and International Journal of Radiation Oncology Biology Physics; Conducting studies of cancer stem cells and their role in determining patient treatment outcomes
Education Certifications:
Protection of Human Subjects in Research; Care and Use of Animals in Research; Transport of Hazardous Biomedical and Radioactive Materials
Marquis Who's Who in the World (2006-Present); Honored for Commitment to Excellence in Graduate Medical Education, by the President of SUNY Downstate Medical Center and the Residents and Fellows of the Alumni Society (2008); Lifetime Honorary Consultant, Swietokrzyskie Centrum Onkologii, Poland (2005); Board of Directors and Executive Committee, Sigma Xi, The Scientific Research Society (1999-2005); Knight’s Cross, Order of Merit for Outstanding Contributions to Polish Science and Education, by the President of the Republic of Poland (2004); Barbara Johnson Memorial Award for Outstanding Service to the Community and the Democratic Party (2004); Commissioner, Kosciuszko Foundation (1988-2011); Presidential Certificate of Gratitude for Contributions to Science, Faculty of Science, Presidential Distinguished Lecturer, Hirosaki University, Japan (1979); USDHHS/NIH/NCI Research Career Development Award (1972-1977)
Where Will You Be In 5 Years:
In five years, Dr. Lange hopes to have FDA approval of an assay he developed (patent and patents pending) that measures the sensitivity to proposed treatments of each patient's cancer stem cells. This would permit individualized treatments for each cancer patient using the most effective treatments for them.
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